Products Description of 5-Methoxy-2-Tetralone CAS#32940-15-1
5-Methoxy-2-tetralone (C11H12O2, CAS# 32940-15-1) is a specialized bicyclic ketone widely employed as a key intermediate in medicinal chemistry. It is particularly valued for constructing sertraline-related derivatives and central nervous system (CNS) agents. Physical properties include a yellow-to-orange solid appearance with a defined melting point of 32–36°C.
5-Methoxy-2-tetralone Chemical Properties
| Melting point | 32-36 °C (lit.) |
| Boiling point | 165°C/10mmHg(lit.) |
| density | 1.124±0.06 g/cm3(Predicted) |
| vapor pressure | 0.059Pa at 25℃ |
| Fp | >230 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform, Dichloromethane, Ethyl Acetate, Methanol |
| form | Solid |
| color | Yellowish Orange |
| BRN | 1451623 |
| InChIKey | MDAIAXRTLTVEOU-UHFFFAOYSA-N |
| LogP | 1.8 at 25℃ |
| CAS DataBase Reference | 32940-15-1(CAS DataBase Reference) |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 26-36-24/25 |
| WGK Germany | 3 |
| HS Code | 29145090 |
Product Application
5-Methoxy-2-tetralone is a core building block in the synthesis of a variety of bioactive molecules:
Featuring a versatile substituted tetralone scaffold, this compound serves as a critical starting material for complex bioactive molecules and advanced chemical research:
Active Pharmaceutical Ingredient (API) Synthesis: Serves as an essential intermediate in the production of Rotigotine, a prominent non-ergot dopamine receptor agonist used to manage Parkinson's disease and Restless Legs Syndrome (RLS).
Neurological & CNS Research: Widely used in medicinal chemistry to construct novel neurotransmitter modulators, including specialized serotonin and dopamine receptor ligands.
Organic Synthesis & Chemical R&D: Functions as a valuable precursor in academic and industrial research for assembling functionalized naphthalene derivatives and polycyclic aromatic frameworks.
