Product Description of Acetylacetone CAS#123-54-6
Acetylacetone is a clear, colorless to pale yellow liquid characterized by a distinctive and pungent odor. It has a melting point of -23℃ and a boiling point of 140.4℃, with a refractive index (n²⁰D) of 1.4520 and a relative density of 0.975.
Acetylacetone exhibits excellent solubility in a variety of organic solvents, including ethanol, ether, chloroform, acetone, and glacial acetic acid, while also showing solubility in water. Due to its chemical properties, the product is flammable and corrosive, and appropriate safety precautions should be taken during storage and handling.
Acetylacetone Chemical Properties
| Melting point | -23 °C (lit.) |
| Boiling point | 140.4 °C (lit.) |
| density | 0.975 g/mL at 25 °C (lit.) |
| vapor density | 3.5 (vs air) |
| vapor pressure | 6 mm Hg ( 20 °C) |
| refractive index | n20/D 1.452(lit.) |
| Fp | 66 °F |
| storage temp. | Store below +30°C. |
| solubility | H2O: soluble1 in 8 parts |
| pka | 8.9(at 25℃) |
| form | Liquid |
| color | very deep green-yellow |
| Relative polarity | 0.571 |
| PH | 6 (200g/l, H2O, 20℃) |
| Odor | pleasant odor |
| explosive limit | 2.4-11.4%(V) |
| Water Solubility | 16 g/100 mL (20 ºC) |
| Merck | 14,81 |
| BRN | 741937 |
| Exposure limits | No exposure limit has been set. |
| Dielectric constant | 23.1（20℃） |
| InChIKey | YRKCREAYFQTBPV-UHFFFAOYSA-N |
| LogP | 0.68 at 20℃ |
| CAS DataBase Reference | 123-54-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Acetylacetone(123-54-6) |
| EPA Substance Registry System | Acetylacetone (123-54-6) |
| Hazard Codes | Xn,Xi |
| Risk Statements | 11-36/37/38-22-10-R22-R10-20/21/22-2017/10/22 |
| Safety Statements | 21-23-24/25-36-26-S24/25-S23-S21 |
| RIDADR | UN 2310 3/PG 3 |
| WGK Germany | 1 |
| RTECS | SA1925000 |
| F | 46288 |
| Autoignition Temperature | 662 °F |
| TSCA | Yes |
| HS Code | 2914 19 90 |
| HazardClass | 3 |
| PackingGroup | III |
| Hazardous Substances Data | 123-54-6(Hazardous Substances Data) |
| Toxicity | LC50 (4 hrs) in rats: 1000 ppm (Carpenter) |
Applications of Acetylacetone CAS#123-54-6
Acetylacetone is widely recognized as a versatile intermediate for organic synthesis. It readily reacts with guanidine to form amino-4,6-dimethylpyrimidine, making it a useful starting material in the manufacture of pharmaceutical products.
Beyond pharmaceutical applications, acetylacetone is utilized in a variety of industrial fields. It serves as a solvent for cellulose acetate, an additive in gasoline and lubricating oils, and a drying agent for paints and varnishes. It is also employed as a fungicide and insecticide. In petroleum processing, acetylacetone can act as a catalyst or reaction promoter in petroleum cracking, hydrogenation, and carbonylation processes, as well as an oxidation promoter
Additionally, acetylacetone can be used to remove metal oxides from porous materials and in the treatment of polypropylene catalysts. In Europe and the United States, more than half of the total acetylacetone consumption is reported to be associated with applications including antidiarrheal pharmaceuticals and livestock feed additives.
